C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients

Table 3 Univariate and multivariate Cox regression analyses of risk factors for progression free survival.

	UnivariateHR (95%CI)	P value	MultivariateHR (95%CI)	P value
Age (yr)
≤ 60	1.0
> 60	1.036 (0.706-1.521)	0.856
Gender
Male	1.0
Female	1.181 (0.765-1.824)	0.453
Aetiology
Other	1.0
Viral hepatitis	1.535 (0.962-2.450)	0.072
ECOG PS
0	1.0
≥ 1	1.258 (0.881-1.797)	0.206
Child-Pugh grade
A	1.0
B	1.430 (0.926-2.208)	0.106
AFP (ng/mL)
≤ 400	1.0
> 400	1.321 (0.943-1.849)	0.105
PIVKA-II (mAU/mL)
≤ 100	1.0
> 100	1.013 (0.698-1.471)	0.944
CAR
≤ 1.20	1.0
> 1.20	3.467 (2.342-5.132)	0.000	2.730 (1.502-4.961)	0.001
Tumor size (cm)
≤ 5	1.0
> 5	1.295 (0.882-1.901)	0.188
Tumor number
Single	1.0
Multiple	1.653 (1.054-2.591)	0.028	1.584 (1.003-2.500)	0.048
Extrahepatic metastasis
-	1.0
+	1.154 (0.827-1.609)	0.400
Macrovascular invasion
-	1.0
+	1.083 (0.774-1.514)	0.642
Diabetes
No	1.0
Yes	0.967 (0.573-1.632)	0.900
Hypertension
No	1.0
Yes	0.969 (0.613-1.530)	0.892
Smoke
No	1.0
Yes	1.349 (0.962-1.892)	0.082
Drink
No	1.0
Yes	1.091 (0.781-1.524)	0.609
Cirrhosis
No	1.0
Yes	1.169 (0.837-1.632)	0.360
Previous TACE
No	1.0
Yes	0.905 (0.646-1.267)	0.561
Previous ablation
No	1.0
Yes	1.361 (0.806-2.297)	0.249
Previous operation
No	1.0
Yes	1.143 (0.812-1.609)	0.442
CRP (mg/L)	1.014 (1.008-1.019)	0.000
ALB (g/L)	0.950 (0.918-0.983)	0.004
AST (U/L)	1.001 (0.997-1.004)	0.771
ALT (U/L)	0.999 (0.993-1.005)	0.643
PLR	1.000 (0.998-1.002)	0.733
LCR	0.064 (0.006-0.722)	0.026
NLR	1.092 (1.006-1.186)	0.036	1.120 (1.022-1.228)	0.015

ECOG PS: Eastern Cooperative Oncology Group Performance Status; AFP: Alpha-fetoprotein; PIVKA-II: Protein induced by vitamin K absence II; CAR: C-reactive protein to albumin ratio; HR: Hazard ratio; 95%CI: 95% confidence interval; TACE: Transcatheter arterial chemoembolization; CRP: C-reactive protein; ALB: Albumin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; PLR: Platelet to lymphocyte ratio; LCR: Lymphocyte-C reactive protein ratio; NLR: Neutrophil to lymphocyte ratio.