C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients

Table 2 Univariate and multivariate Cox regression analyses of risk factors for overall survival

	UnivariateHR (95%CI)	P value	MultivariateHR (95%CI)	P value
Age (yr)
≤ 60	1.0
> 60	1.222 (0.763-1.958)	0.403
Gender
Male	1.0
Female	1.127 (0.669-1.898)	0.653
Aetiology
Other	1.0
Viral hepatitis	1.464 (0.810-2.646)	0.207
ECOG PS
0	1.0
≥ 1	2.010 (1.229-3.288)	0.005	1.754 (1.045-2.944)	0.033
Child-Pugh grade
A	1.0
B	1.348 (0.798-2.276)	0.264
AFP (ng/mL)
≤ 400	1.0
> 400	1.401 (0.920-2.133)	0.116
PIVKA-II (mAU/mL)
≤ 100	1.0
> 100	1.942 (1.142-3.302)	0.014
CAR
≤ 1.20	1.0
> 1.20	2.264 (1.480-3.464)	0.000	2.118 (1.057-4.243)	0.034
Tumor size (cm)
≤ 5	1.0
> 5	2.671 (1.451-4.971)	0.002
Tumor number
Single	1.0
Multiple	3.328 (1.452-7.682)	0.004	2.932 (1.246-6.897)	0.014
Extrahepatic metastasis
-	1.0
+	1.121 (0.735-1.709)	0.597
Macrovascular invasion
-	1.0
+	1.550 (1.015-2.367)	0.042
Diabetes
No	1.0
Yes	0.934 (0.467-1.868)	0.848
Hypertension
No	1.0
Yes	0.902 (0.508-1.602)	0.726
Smoke
No	1.0
Yes	1.634 (1.068-2.501)	0.024
Drink
No	1.0
Yes	1.386 (0.911-2.111)	0.128
Cirrhosis
No	1.0
Yes	0.899 (0.589-1.372)	0.622
Previous TACE
No	1.0
Yes	0.897 (0.587-1.371)	0.615
Previous ablation
No	1.0
Yes	0.719 (0.346-1.497)	0.378
Previous operation
No	1.0
Yes	0.555 (0.351-0.878)	0.012
CRP (mg/L)	1.008 (1.002-1.014)	0.005
ALB (g/L)	0.944 (0.902-0.988)	0.013
AST (U/L)	1.006 (1.003-1.010)	0.000
ALT (U/L)	1.004 (0.998-1.011)	0.219
PLR	0.999 (0.997-1.002)	0.562
LCR	0.771 (0.065-9.087)	0.836
NLR	1.036 (0.953-1.126)	0.410

ECOG PS: Eastern Cooperative Oncology Group Performance Status; AFP: Alpha-fetoprotein; PIVKA-II: Protein induced by vitamin K absence II; CAR: C-reactive protein to albumin ratio; HR: Hazard ratio; 95%CI: 95% confidence interval; TACE: Transcatheter arterial chemoembolization; CRP: C-reactive protein; ALB: Albumin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; PLR: Platelet to lymphocyte ratio; LCR: Lymphocyte-C reactive protein ratio; NLR: Neutrophil to lymphocyte ratio.