Cellular senescence throws new insights into patient classification and pharmacological interventions for clinical management of hepatocellular carcinoma

Figure 2 Classification of TCGA-LIHC patients as three cellular senescence subtypes and external dataset validation. A–C: Consensus cumulative distribution function (CDF), relative alteration in area under CDF curve, and consensus matrix k = 3 based upon the transcriptome of prognostic differentially expressed cellular senescence genes across TCGA-LIHC patients; D: The transcript levels of differentially expressed cellular senescence genes with prognostic implications across three subtypes; E: Principal component analysis (PCA) plots of the discrepancy in transcript levels among subtypes; F: Kaplan–Meier (K-M) curves of overall survival in TCGA-LIHC; G: Nearest template prediction for verifying the subtypes in the International Cancer Genome Consortium (ICGC) cohort; H and I: PCA plots of the transcriptome difference and K-M curves of overall survival among subtypes in the ICGC cohort.