MicroRNA-363-3p inhibits colorectal cancer progression by targeting interferon-induced transmembrane protein 1

Figure 4 Expression levels of significance and interferon-induced transmembrane protein 1 are negatively correlated in human colorectal cancer tissues. A: Quantitative polymerase chain reaction analysis of interferon-induced transmembrane protein 1 (IFITM1) mRNA expression in colorectal cancer tissues and paired normal colorectal tissues; B: Representative images of IFITM1 expression detected by immunohistochemical staining. Immunohistochemical (IHC) scores are shown in the upper left corner, and the scale bar is 50 μm. Violin plots show statistical analysis of IHC scores; C: IFITM1 mRNA expression levels in colon cancer and normal colon tissues (left panel), rectal cancer, and normal rectal tissues (right panel) were analyzed using TCGA and GTEx databases; D: Correlation analysis of IFITM1 mRNA expression level and overall survival in patients with colon cancer (left panel) or rectal cancer (right panel); E: Correlation analysis of IFITM1 mRNA expression level and disease-free survival in patients with colon cancer (left panel) or rectal cancer (right panel); F: Correlation analysis of IFITM1 mRNA expression level and microRNA-363-3p expression level. The results were shown as the mean ± SD. ^aP < 0.05. IHC: Immunohistochemical; IFITM1: Interferon-induced transmembrane protein 1; miR-363-3p: MicroRNA-363-3p; NC: Negative control.