RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer

Figure 4 Knockdown of cleavage and polyadenylation factor 6 inhibits cell proliferation, migration, and invasion but boosts pyroptosis. A: Cell viability was verified after suppressing cleavage and polyadenylation factor 6 (CPSF6) by Cell Counting Kit-8 assay; B and C: Cell migration and invasion were detected after inhibiting CPSF6 by Transwell assay; D: Cell apoptosis was examined after silencing CPSF6 by flow cytometry; E: The protein expression levels of NLR family pyrin domain containing 3, cleaved caspase-1, interleukin-18 (IL-18), and IL-1β were examined after suppressing CPSF6 by Western blot. ^aP < 0.05, ^bP < 0.01. CPSF6: Cleavage and polyadenylation factor 6; NLRP3: NLR family pyrin domain containing 3; IL: Interleukin.