Fibrinogen-to-albumin ratio predicts overall survival of hepatocellular carcinoma

Table 2 Univariate and multivariate Cox proportional hazards model fitting results

Covariates	Univariate Cox model		Multivariate Cox model
	Crude HR (90%CI)	P value	Adjusted HR (95%CI)	P value
Sex: Male	1.74 (1.30, 2.35)	< 0.01
Age at diagnosis: + 5 yr	1.01 (0.96, 1.06)	0.72
Cigarette smoking: Yes	1.51 (1.23, 1.87)	< 0.01
Alcohol drinking: Yes	1.23 (1.01, 1.50)	0.08
BMI: + 1 kg/m2	0.97 (0.93, 1.00)	0.14
Stage (Ref: I-II)
III	3.49 (2.46, 4.96)	< 0.01	2.14 (1.37, 3.35)	< 0.01
IV	4.86 (3.40, 6.95)	< 0.01	2.33 (1.45, 3.74)	< 0.01
AST: 40 U/L	2.74 (2.12, 3.53)	< 0.01	1.50 (1.01, 2.22)	0.04
ALT: 40 U/L	1.72 (1.41, 2.10)	< 0.01
AFP: 400 ng/mL	1.93 (1.58, 2.36)	< 0.01	1.53 (1.19, 1.96)	< 0.01
TBIL: 17.1 μmo/L	1.81 (1.49, 2.20)	< 0.01
NLR: + 5	1.72 (1.45, 2.05)	< 0.01
CEA: 5 U/L	1.26 (1.01, 1.57)	< 0.01
CA125: 35 U/L	2.89 (2.36, 3.55)	< 0.01	1.72 (1.30, 2.27)	< 0.01
CA19-9: > 37 U/L	1.95 (1.60, 2.37)	< 0.01
FAR: 0.081	2.43 (1.95, 3.02)	< 0.01	1.39 (1.05, 1.83)	< 0.01

90%CI: 90% confidence interval; 95%CI: 95% confidence interval; AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BMI: Body mass index; CA125: Carbohydrate antigen 125; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; FAR: Fibrinogen-to-albumin ratio; HR: Hazard ratio; NLR: Neutrophil-to-lymphocyte ratio; TBIL: Total bilirubin.