Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jul 15, 2023; 15(7): 1149-1173
Published online Jul 15, 2023. doi: 10.4251/wjgo.v15.i7.1149

Table 7 G-quadruplexes as anticancer agents

Tumor model	G-quadruplex name	Sequence (5’-3’)	Protein target	Cells	Anticancer phenotype	Ref.
Pancreatic cancer	T-22AG	GGAGGGGGAGAAGGGAGAAGGG	Nuclear protein	Panc-1	Reduces cell growth	[199]
Pancreatic cancer	AS1411	GGTGGTGGTGGTTGTGGTGGTGGTGG	Nucleolin	PANC-1	Inhibited cell proliferation	[200]
Gastric cancer	AS1411	GGTGGTGGTGGTTGTGGTGGTGGTGG	Nucleolin	KATOIIIe, HGC27	Inhibited cell proliferation	[200]
Colorectal cancer	AS1411	GGTGGTGGTGGTTGTGGTGGTGGTGG	Nucleolin	HCC 2998, HT-29, KM12, HCT-116, SW620, HCT-15, LS174T	Inhibited cell proliferation	[200]
	TBA	GGTTGGTGTGGTTGG	uL3	HCT 116p53^-/-	Impaired ribosomal RNA processing, leading to the accumulation of pre-ribosomal RNAs, arrested cells in the G2/M phase and induced early apoptosis	[201]
	L-TBA	GGTTGGTGTGGTTGG
	LQ1	GGTTGGTGTGGTTGG
	LQ2	GGTTGGGTGTGGTTGG
	LQ3	GGTTGGGTGTGGTTGG
	INT-B (T30175)	GTGGTGGGTGGGTGGGT	Not detected	HCT 116p53^-/-	Inhibited cell proliferation	[202]
	INT-BS2	GSGGTGGGTGGGTGGGT
	INT-BS5	GTGGSGGGTGGGTGGGT
	INT-BS9	GTGGTGGGSGGGTGGGT
	INT-BS13	GTGGTGGGTGGGSGGGT
	INT-BS17	GTGGTGGGTGGGTGGGS
	TT-INT-B	TTGTGGTGGGTGGGTGGGT
	Qnat	GGGTGGGTGGGTGGGT	Not detected	HCT 116p53^-/-	Inhibited cell proliferation	[203]
	QS4	GGGSGGGTGGGTGGGT
	QS8	GGGTGGGSGGGTGGGT
	QS12	GGGTGGGTGGGSGGGT
	QS16	GGGTGGGTGGGTGGGS

Citation: Han ZQ, Wen LN. Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects. World J Gastrointest Oncol 2023; 15(7): 1149-1173
URL: https://www.wjgnet.com/1948-5204/full/v15/i7/1149.htm
DOI: https://dx.doi.org/10.4251/wjgo.v15.i7.1149

Han ZQ, Wen LN. Application of G-quadruplex targets in gastrointestinal cancers: Advancements, challenges and prospects. World J Gastrointest Oncol 2023; 15(7): 1149-1173 [PMID: 37546556 DOI: 10.4251/wjgo.v15.i7.1149]

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