5’tiRNA-Pro-TGG, a novel tRNA halve, promotes oncogenesis in sessile serrated lesions and serrated pathway of colorectal cancer

Figure 1 Expression profiles of transfer RNA-related fragments and transfer RNA halves in paired sessile serrated lesions and normal control groups. A: Hierarchical clustering analysis of transfer RNA (tRNA)-related fragment (tRF)- and tRNA halves (tiRNAs)-expression data obtained from paired sessile serrated lesions (SSLs) and normal control (NC) groups. Cluster analysis arranged samples into groups based on the counts per million. All samples were categorized in 10 clusters using K-means clustering. B: Principal component analysis showed a distinguishable tRF- and tiRNA-expression profile among SSLs and NC. C: Venn diagram based on the number of basically expressed and specifically expressed tRFs and tiRNAs. D: Heatmap revealed results of dysregulated tRFs and tiRNAs obtained using hierarchical clustering analysis. SSLs: Sessile serrated lesions; NC: Normal control; PCA: Principal component analysis.