Mitophagy-related gene signature predicts prognosis, immune infiltration and chemotherapy sensitivity in colorectal cancer

Figure 8 CXCL3 attenuates mitophagy in colorectal cancer cells. A: Differentially expressed mitophagy related genes included in the signature; B: quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) and Western blot showing enforced expression of CXCL3 in colorectal cancer (CRC) cells; C: CXCL3 overexpression significantly enhanced cell proliferation and cell viability; D: CXCL3 overexpression weakened the sensitivity of CRC cells to oxaliplatin treatment; E and F: The mtDNA of CRC cells with or with CXCL3 overexpression was detected using qRT-PCR. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.