Xiaojianzhong decoction prevents gastric precancerous lesions in rats by inhibiting autophagy and glycolysis in gastric mucosal cells

Figure 1 Effects of Xiaojianzhong decoction on body weight, gastric mucosal pathological conditions and liver kidney toxicity in N-methyl-N’-nitro-N-nitrosoguanidine-induced gastric precancerous lesions rats. A: Schematic diagram of model construction and treatment; B: Schematic diagram of weight change in rats; C: Representative images of hematoxylin-eosin and alcian blue-periodic acid-Schiff staining of gastric tissues; D-G: Ki-67 and caudal-type homeobox protein 2 (CDX-2) expression was determined using immunohistochemistry (n = 5); Ki-67 and CDX-2 positive score was determined using Image J; H: Superoxide dismutase and malondialdehyde levels in serum (n = 3); I: Alanine aminotransferase and creatinine levels in serum (n = 3). Data are expressed as mean ± SD. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs control group; ^dP < 0.05, ^eP < 0.01, ^fP < 0.001 vs model group. XJZ-L: Low dose of Xiaojianzhong decoction; XJZ-M: Middle dose of Xiaojianzhong decoction; XJZ-H: High dose of Xiaojianzhong decoction; SOD: Superoxide dismutase; MDA: Malondialdehyde; ALT: Alanine aminotransferase; Cr: Creatinine.