Immunotherapy for advanced or recurrent hepatocellular carcinoma

Table 3 Activity of combinations of an immune checkpoint inhibitor and a vascular endothelial growth factor inhibitor from clinical trials

Drugs	Other treatment	Targets	Trial identifier	Patient group	n	mOS in mo	ORR, %	DCR, %	mPFS in mo	Phase	Setting
Atezolizumab + bevacizumab	vs Sorafenib	PD-L1; VEGF	NCT03434379	Unresectable HCC	326	19.20	27.3	74.0	6.90	III	1L
Pembrolizumab + lenvatinib	No	PD-1; VEGFR	NCT03006926	Unresectable HCC	104	22.00	36.0	88.0	8.60	Ib	1L
Sintilimab + IBI305	vs Sorafenib	PD-1; VEGF	NCT03794440	Unresectable HCC	380	NR	21.0	72.0	4.60	III	1L
Atezolizumab + cabozantinib	vs Sorafenib	PD-L1; VEGFR	NCT03755791	Advanced HCC	432	15.40	11.0	78.0	6.10	III	1L
Camrelizumab + apatinib	No	PD-1; VEGFR	NCT03463876	Advanced HCC	70	NR	34.3	77.1	5.70	II	1L
Camrelizumab + apatinib	No	PD-1; VEGFR	NCT03463876	Advanced HCC	120	NR	22.5	75.8	5.50	II	2L

1L: First-line therapy; 2L: Second-line therapy; CTLA-4: Cytotoxic T lymphocyte-associated antigen 4; DCR: Disease control rate; HCC: Hepatocellular carcinoma; mOS: Median overall survival; mPFS: Median progression free survival; NR: Not reached; ORR: Overall response rate; PD-1: Programmed cell death protein 1; PD-L1: Programmed death ligand 1; VEGF: Vascular endothelial growth factor; VEGFR: Vascular endothelial growth factor receptor.