Prognostic value of claudin 18.2 expression in gastric adenocarcinoma

Table 1 Clinicopathological characteristics of patients with gastric adenocarcinoma based on claudin 18.2 expression

Parameter	Number of cases		CLDN18.2 score								P value
			0		1		2		3
	n	%	n	%	n	%	n	%	n	%
Age in yr
< 65	30	46.2	4	13.3	10	33.3	9	30.0	7	23.3	0.091
≥ 65	35	53.8	13	37.1	10	28.6	5	14.3	7	20.0
Sex
Male	49	75.4	14	28.6	15	30.6	11	22.4	9	18.4	0.314
Female	16	24.6	3	18.8	5	31.3	3	18.8	5	31.3
Lauren classification
Intestinal	41	63.1	9	22.0	12	29.3	10	24.4	10	24.4	0.221
Diffuse	24	39.9	8	33.3	8	33.3	4	16.7	4	16.7
Tumor grade
G1	30	46.2	9	30.0	8	26.7	7	23.3	6	20.0	0.889
G2	8	12.3	1	12.5	3	37.5	2	25.0	2	25.0
G3	27	41.5	7	25.9	9	33.3	5	18.5	6	22.2
Localization
Cardia	18	27.7	3	16.7	9	50.0	3	16.0	3	16.7	0.307
Corpus	10	18.5	4	33.3	5	41.7	1	8.3	2	16.7
Antrum	12	15.4	3	30.0	3	30.0	2	20.0	2	20.0
Pylorus	2	2.1	0	0.0	0	0.0	2	100.0	0	0.0
Antropyloric	23	35.4	7	30.4	3	13.0	6	26.1	7	30.4
Her2Neu
Negative	54	83.1	13	24.1	15	27.8	13	24.1	13	24.1	0.116
Positive	11	16.9	4	36.4	5	45.5	1	9.1	1	9.1
Family history
No	40	61.5	13	32.5	9	22.5	10	25.0	8	20.0	0.751
Yes	14	21.5	2	14.3	6	42.9	2	14.3	4	28.6
Unknown	11	16.9	2	18.2	5	45.5	2	18.2	2	18.2
Liver metastasis
No	33	50.8	8	25.0	10	31.3	6	18.8	8	25.00	0.703
Yes	32	49.2	9	27.3	10	30.3	8	24.2	6	18.2
Lung metastasis
No	48	73.2	9	52.9	3	17.6	2	11.8	3	17.6	0.053
Yes	17	26.8	8	16.7	17	35.4	12	25.0	11	22.9
Metastasis sites
Liver	16	24.6	2	12.5	7	43.8	2	12.5	5	31.3	0.050
Lung	4	6.2	2	50.0	0	0.0	0	0.0	2	50.0
Peritoneum	11	16.9	0	0.0	5	45.5	3	27.3	3	27.3
LAP	14	21.5	4	28.6	2	14.3	6	42.90	2	14.30
Brain	2	3.1	2	100.0	0	0.0	0	0.0	0	0.0
Liver + lung	17	26.2	7	41.2	6	35.0	2	11.8	2	11.8
Ovary	1	1.5	0	0.0	0	0.0	1	100.0	0	0.0
Adjuvant chemotherapy
No	29	44.6	8	27.6	9	31.0	6	20.7	6	20.7	0.793
Yes	36	55.4	9	25.0	11	30.6	8	22.2	8	22.2
Neoadjuvant chemotherapy
No	61	91.8	14	23.0	20	32.8	13	21.3	14	23.0	0.097
Yes	4	8.2	3	75.0	0	0.0	1	25.0	0	0.0
Exitus
No	7	10.8	0	0.0	3	42.9	3	42.9	1	14.3	0.401
Yes	58	89.2	17	29.3	17	29.3	11	19.0	13	22.4

CLDN18.2: Claudin 18.2; LAP: Lymphadenopathy.