Challenges to addressing the unmet medical needs for immunotherapy targeting cold colorectal cancer

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Feb 15, 2023; 15(2): 215-224
Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.215

Table 1 Key categories for non-clinical strategies to overcome obstacles in cancer immunotherapy

Strategy	Therapeutic approach	Ref.
Increase in antigen-specific T-cells and T-cell priming	Adoptive cell therapy (CAR-T and -NK)	[30-44,49]
	Adjuvant immunotherapy
	Epigenetic modification inhibitors
	Cancer vaccine
	Oncolytic viruses
	Combined with conventional therapies
Promoting T-cell trafficking and infiltration	TGF-β suppression	[50-58,60,61]
	Oncogenic pathway inhibitors
	Angiogenesis inhibitors
	CXCR4 inhibitors
	Immunocytokines

CAR: Chimeric antigen receptor; NK: Natural killer; TGF: Transforming growth factor; CXCR: C-X-C motif chemokine receptor.

Citation: Jeong KY. Challenges to addressing the unmet medical needs for immunotherapy targeting cold colorectal cancer. World J Gastrointest Oncol 2023; 15(2): 215-224
URL: https://www.wjgnet.com/1948-5204/full/v15/i2/215.htm
DOI: https://dx.doi.org/10.4251/wjgo.v15.i2.215

Jeong KY. Challenges to addressing the unmet medical needs for immunotherapy targeting cold colorectal cancer. World J Gastrointest Oncol 2023; 15(2): 215-224 [PMID: 36908316 DOI: 10.4251/wjgo.v15.i2.215]

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