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©The Author(s) 2023.
World J Gastrointest Oncol. Feb 15, 2023; 15(2): 215-224
Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.215
Published online Feb 15, 2023. doi: 10.4251/wjgo.v15.i2.215
Table 1 Key categories for non-clinical strategies to overcome obstacles in cancer immunotherapy
| Strategy | Therapeutic approach | Ref. |
| Increase in antigen-specific T-cells and T-cell priming | Adoptive cell therapy (CAR-T and -NK) | [30-44,49] |
| Adjuvant immunotherapy | ||
| Epigenetic modification inhibitors | ||
| Cancer vaccine | ||
| Oncolytic viruses | ||
| Combined with conventional therapies | ||
| Promoting T-cell trafficking and infiltration | TGF-β suppression | [50-58,60,61] |
| Oncogenic pathway inhibitors | ||
| Angiogenesis inhibitors | ||
| CXCR4 inhibitors | ||
| Immunocytokines |
- Citation: Jeong KY. Challenges to addressing the unmet medical needs for immunotherapy targeting cold colorectal cancer. World J Gastrointest Oncol 2023; 15(2): 215-224
- URL: https://www.wjgnet.com/1948-5204/full/v15/i2/215.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v15.i2.215