MUTYH-associated polyposis: Is it time to change upper gastrointestinal surveillance? A single-center case series and a literature overview

Table 3 Literature review of duodenal cancers in MUTYH-associated polyposis

Study design	Number of MAP patients	Main findings	Ref.
Cohort study	394	None of the four MAP-associated duodenal cancers (about 1%) reported in this cohort study developed in the context of prior stage IV disease. Three of them involved the distal duodenum	[11]
Retrospective study	92	One duodenal and one ampullary cancer occurred in this cohort (about 2%), none in the context of prior stage IV disease	[9]
European multicenter study	276	Duodenal polyposis occurred in 17% of patients who underwent esophagogastroduodenoscopy. SS classification was not presented. Two duodenal cancers were reported (about 1%)	[10]

MAP: MUTYH-associated polyposis; SS: Spigelman stage.