Conditional survival probability of distant-metastatic hepatocellular carcinoma: A population-based study

Table 2 Multivariate analyses of factors associated with overall survival and cancer-specific survival

Characteristics	Overall survival		Cancer-specific survival
	HR	P value	HR	P value
Age, yr
< 55
55-65	1.03 (0.89-1.19)	0.67	0.98 (0.85-1.13)	0.78
≥ 65	1.09 (0.94-1.26)	0.27	1.02 (0.88-1.19)	0.77
Gender
Female
Male	1.1 (0.96-1.26)	0.18	1.07 (0.93-1.24)	0.35
Race
Black
White	1.03 (0.89-1.2)	0.67	1.09 (0.93-1.27)	0.29
Other	1.12 (0.93-1.34)	0.23	1.2 (0.99-1.45)	0.063
Marital status
Married
Single	1.00 (0.88-1.14)	0.96	0.95 (0.83-1.08)	0.42
Separated	0.93 (0.82-1.07)	0.31	0.86 (0.75-0.99)	0.038
AFP expression
Negative
Positive	1.35 (1.17-1.56)	5.02E-05	1.33 (1.16-1.52)	5.70E-05
Tumor size
> 5 cm
≤ 5 cm	0.86 (0.74-1.00)	0.057	0.97 (0.83-1.13)	0.69
T stage
T1
T2	1.15 (0.95-1.39)	0.16	0.98 (0.8-1.2)	0.85
T3	1.27 (1.1-1.46)	1.03E-03	1.24 (1.07-1.42)	3.30E-03
T4	1.27 (1.04-1.54)	0.18	1.29 (1.07-1.56)	7.30E-03
N stage
N0
N1	1.19 (1.06-1.33)	3.89E-03	1.12 (0.99-1.27)	0.062
Surgery
No
Yes	0.42 (0.32-0.54)	7.65E-12	0.51 (0.41-0.64)	1.50E-09
Chemotherapy
No/unknown
Yes	0.59 (0.53-0.66)	1.42E-21	1.39 (1.25-1.56)	2.40E-09
Radiotherapy
No/unknown
Yes	0.71 (0.61-0.83)	1.40E-05	1.25 (1.09-1.42)	9.00E-04
Lung metastasis
No
Yes	1.36 (1.22-1.52)	9.97E-08	1.29 (1.15-1.45)	1.60E-05
Bone metastasis
No
Yes	1.22 (1.07-1.39)	3.76E-03	1.24 (1.08-1.41)	1.70E-03
Brain metastasis
No
Yes	0.97 (0.65-1.44)	0.89	0.96 (0.61-1.5)	0.85

AFP: α-fetoprotein; HR: Hazard ratio.