Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis

Figure 4 Circ_0001658 affects the growth, apoptosis and cycle of colorectal cancer cells by adsorption of miR-590-5p. Circ_0001658 was co-transfected with mimics into HT29 cells and si-circ-2 and inhibitors into SW480 cells. A: miR-590-5p expression was probed by quantitative real-time polymerase chain reaction; B-F: The effects of circ_0001658 and miR-590-5p on cell proliferation, apoptosis and cell cycle were detected by cell countering kit-8 assay and flow cytometry. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. NC: Negative control; circ-OE: Circ_0001658 plasmid; si-NC: siRNA negative control; OD: Optical density.