Predictors for malignant potential and deep submucosal invasion in colorectal laterally spreading tumors

Table 4 Univariate and multivariate analyses of predictors for submucosal invasion and deep submucosal invasion

	Univariate		Multivariate
	OR (95%CI)	P value	OR (95%CI)	P value
Risk factors for SMI
LST subtype
Non-NG-PD	1	-	1	-
NG-PD	8.6 (3.9-18.7)	< 0.001	9.1 (3.9-21.0)	< 0.001
Location
Non-rectosigmoid	1	-	1	-
Rectosigmoid	2.9 (1.3-6.3)	0.007	3.2 (1.4-7.6)	0.007
Non-lifting sign
Negative	1	-	1	-
Positive	4.8 (2.0-11.3)	< 0.001	3.0 (1.2-8.0)	0.023
Risk factors for deep SMI
LST subtype
Non-NG-PD	1		1
NG-PD	11.3 (3.3-39.1)	< 0.001	13.3 (3.7-47.9)	< 0.001
Location
Non-rectosigmoid	1		1
Rectosigmoid	7.8 (1.7-36.2)	0.009	8.7 (1.8-42.3)	0.007
Non-lifting sign
Negative	1
Positive	5.2 (1.5-18.6)	0.010

LST: Laterally spreading tumor; NG-PD: Non-granular pseudodepressed; OR: Odds ratio; CI: Confidence interval; SMI: Submucosal invasion.