Increased 5-hydroxymethylcytosine is a favorable prognostic factor of Helicobacter pylori-negative gastric cancer patients

Table 2 5-hydroxymethylcytosine level stratified by different characteristics according to Helicobacter pylori infection condition

Characteristics	H. pylori (-), n = 55		H. pylori (+), n = 89
	5-hmC high, n (%)	P value	5-hmC high, n (%)	P value
Sex
Male	18 (50.0)	0.013	28 (44.4)	0.883
Female	16 (84.2)		12 (46.2)
Age in yr
< 60	10 (55.6)	0.505	11 (28.9)	0.009
≥ 60	24 (64.9)		29 (56.9)
Histological grade
High	10 (55.6)	0.505	5 (25.0)	0.042
Low	24 (64.9)		35 (50.7)
WHO classification
Tubular adenocarcinoma	31 (60.8)	11	29 (45.3)	0.911
Others	3 (75.0)		11 (44.0)
Tumor size in cm
< 5	13 (61.9)	0.992	17 (41.5)	0.542
≥ 5	21 (61.8)		23 (47.9)
Vascular invasion
Negative	10 (52.6)	0.308	6 (30.0)	0.127
Positive	24 (66.7)		34 (49.3)
Neural invasion
Negative	16 (57.1)	0.467	9 (25.0)	0.002
Positive	18 (66.7)		31 (58.5)
Depth of invasion
T1/T2	12 (50.0)	0.112	12 (40.0)	0.504
T3/T4	22 (71.0)		28 (47.5)
Lymph metastasis
N0	9 (50.0)	0.208	8 (34.8)	0.255
N1/N2/N3	25 (67.6)		32 (48.5)
TNM stage
Ⅰ + Ⅱ	17 (54.8)	0.226	13 (31.0)	0.012
Ⅲ	17 (70.8)		27 (57.4)
Chemotherapy
No	19 (61.3)	0.927	23 (52.3)	0.169
Yes	15 (62.5)		17 (37.8)

¹P value of Fisher’ exact test. 5-hmC: 5-hydroxymethylcytosine; H. pylori: Helicobacter pylori; WHO: World Health Organization.