Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α

Figure 2 Berberine inhibited hepatocyte nuclear factor 4α expression in MGC803 and SGC7901 xenograft tumor models. A: Immunohistochemistry showed that berberine reduced the expression of hepatocyte nuclear factor 4α (HNF4α) in tumor tissues of MGC803 and SGC7901 xenograft tumor models; B: The quantification of immunohistochemistry of the expression of HNF4α in tumor tissues of MGC803 and SGC7901 xenograft tumor models; C: The effect of berberine on HNF4α mRNA expression in tumor tissues of MGC803 and SGC7901 xenograft tumor models; D: The effect of berberine on HNF4α protein expression in tumor tissues of MGC803 and SGC7901 xenograft tumor models; E: The effect of berberine on HNF4α mRNA level in liver tissues of MGC803 and SGC7901 xenografts; F: The effect of berberine on HNF4α protein expression in liver tissues of MGC803 and SGC7901 xenografts. ^aP < 0.05, ^bP < 0.01, ^dP < 0.0001. Ctrl: The control group; BBR: The berberine group.