RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and potential biomarkers

Figure 3 Verification of the sensitivity to 5-fluorouracil and differential circular RNA expression in 4 cell lines. A-D: The inhibition rate of 5-fluorouracil (5-Fu) in these 4 paired cell lines was detected using the WST-1 assay at 48 h; E-H: Relative expression of 5 circular RNAs (hsa_circ_0002813, hsa_circ_0000236, hsa_circ_0122168, hsa_circ_0031584, and hsa_circ_0006877) in 4 paired cell lines was measured using quantitative real-time polymerase chain reaction assays. Data are presented as means ± SD. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. NS: No significant difference; 5-Fu: 5-fluorouracil.