Case Report
Copyright ©The Author(s) 2022.
World J Gastrointest Oncol. Dec 15, 2022; 14(12): 2404-2414
Published online Dec 15, 2022. doi: 10.4251/wjgo.v14.i12.2404
Table 2 Gastric signet ring cell adenocarcinoma
Patients
Sex/age
Sites of skin involvement
Initial present symptoms
Stage
Follow-up
Management
Ref.
1Male/67Nodular lesions on his eyelid, cheeks, scalp, and backWeight loss of 8 kg within 1 moNot availableDOD 3 mo after skinXELOX chemotherapy (oxaliplatin and capecitabine)[23]
2Male/69On forehead, back, neck, and armsDysphagia from eating and multiple cutaneous nodulesNot availableDOD 1 mo after skinSurgery[24]
3Female/53On abdomen and thighsLivedo reticularisNot availableDOD 7 mo after skinChemoradiation[25]
4Female/72Skin infiltration in the lower limbs, abdomen, and root of the upper limbsLymphangitisStage IIIa DOD 5 mo after skinAdjuvant chemotherapy with capecitabine + oxaliplatin[26]
5Female/75On the abdomenIndurated scarlike lesions on the epigastric areaStage IIIa (T4aN1M0)DOD 3 mo after skinChemotherapy (5-fluorouracil, infusional folinic acid, and oxaliplatin)[27]
6Female/57On the abdomenWith growing lesions on skinStage IIIa (T3N2M0)Not availableAdjuvant chemotherapy [infusional folinic acid + 5-fluorouracil] and radiotherapy, a second round of chemotherapy[20]
7Female/45On head and the backThe cutaneous metastases disappearedSurvivalChemotherapy with S-1 (Tegafur) plus cisplatin [28]
8Male/52Armpits, axillae, groin, and neck foldsProgressive dermal, mucosal, and perianal lesions, weight lossT3N2M1Not availableN/A[18]
9Male/21Cutaneous nodule on his chestCutaneous noduleStage IVSurvivalChemotherapy with oxaliplatin (day 1) and S-1[29]
10Male/85A lesion of the right occipital scalpAbdominal pain, malaiseT4N1M0DOD 5 mo after skinNot available[30]
11Male/35Cutaneous nodules on the upper chest, abdomen and left scapular regionWithout any local or general clinical symptomsNot availableNot availableNot available[15]
12Male/76Skin ulcer on right hypochondriumHematemesis, weight loss and loss of appetiteT4N2M0DOD 1 mo after skinChemotherapy with irinotecan and oxaliplatin[16]
13Female/50Large erythematous plaque on the left side of the neck; and an erythematous lesion in the perineal regionBowel habit and weight lossNot availableDOD 0.5 mo after skinNot available[31]
14Male/59Painless nodule of the left flankPainless nodule of the left flankNot availableDOD 0.5 mo after skinMetastatic infiltration of a 32-yr-old surgical scar[32]
15Male/50The umbilical areaWith a single asymptomatic skin lesionNot availableNot availableNot available[19]
16Male/69Asymptomatic indurated scar-like lesionAsymptomatic indurated scar-like lesionStage IVDOD 10 mo after skinChemotherapy with cisplatin, Taxotere, and xeloda[33]
17Female/71Limited cyan erythema on the right side of the middle and lower abdomenAbdominal skinNot availableDOD 12 mo after skinChemotherapy (unknown medication)[34]
18Male/48Bracelet bracelet ("tripe palm"); and hyperkeratosis of fingersSkin edema with pigmentationNot availableDOD 36 mo after skinChemotherapy with cisplatin, 5-fluorouracil and folic acid[35]
19Male/44Multiple cutaneous eruptions on face and neckVomiting and weight lossNot availableN/ANot available[17]
20Male/51Abdominal and backWithout any symptomNot availableDOD 2 mo after skinSurgery[36]
21Male/67Diffuse erythematous and warm induration over his right cheek and neckDyspepsiaStage IVDOD 0.75 mo after skinRadiotherapy[37]
22Male/55Lower part of face and neckWith multiple itchy nodulesNot availableDOD 7~8 mo after skinNot available[21]
23Female/58Right inguinal erythema with itchingWith chylothoraxNot availableDOD 4 mo after skinNot available[38]
24Male/44On the face, trunk, and upper extremitiesMultiple cutaneous nodulesStage IVSurvivalChemotherapy with an oxaliplatin-based regimen and denosumab[39]
25Male/68Right chin region and on the left foreheadErythematous skin lesion, nodular skin lesionT4N0M0Not availableSurgical treatment[40]