Neoadjuvant therapy in resectable pancreatic cancer: A promising curative method to improve prognosis

Table 6 Comparison of resection margin status between the upfront surgery group and the neoadjuvant therapy plus surgery group

Ref.	Country	NCT number/Name	Variable	Upfront surgery	NAT plus surgery	P value
Golcher et al[7]	Germany	NCT00335543	Resection rate	23/33 (70%)	19/33 (58%)	0.31
			R0 rate	16/23 (70%)	17/19 (89%)	NM
			ITT R0 rate	16/33 (48%)	17/33 (52%)	0.81
Versteijne et al[8]	Netherlands	PREOPANC	Resection rate	54/68 (79%)	44/65 (68%)	0.17
			R0 rate	32/54 (59%)	29/44 (66%)	0.54
			ITT R0 rate	32/68 (47%)	29/65 (45%)	NM
Casadei et al[9]	Italy	-	Resection rate	15/20 (75%)	11/18 (61%)	0.489
			R0 rate	5/15 (33%)	7/11 (64%)	NM
			ITT R0 rate	5/20 (25%)	7/18 (39%)	0.489
Reni et al[10]	Italy	PACT-15	Resection rate	49/56 (88%)	27/32 (84%)	NM
			R0 rate	16/49 (33%)	17/27 (63%)	NM
			ITT R0 rate	16/56 (29%)	17/32 (53%)	NM

NAT: Neoadjuvant therapy; NM: Not mentioned; ITT: Intention to treat.