Gastric cancer: An epigenetic view

Table 5 Examples of epigenetic drugs in gastric cancer

Drugs	Targets	Status	Ref.
Clinical
Vorinostat + capecitabine + cisplatin	HDAC	Completed phase II test	[167]
Vorinostat + folinic acid+ 5‑fluorouracil+ irinotecan	HDAC	Completed phase I test	[168]
Azacytidine + epirubicin/oxaliplatin/capecitabine	DNMT	Completed phase I test	[169]
Cholecalciferol + HDACi	HDAC	Induce apoptosis in GC cells; Prevent bone loss in preliminary trials;	[170,171]
Preclinical
SAHA	HDAC	Suppress proliferation, induce apoptosis, chemosensitivity in GC cells	[172,173]
LBH589	HDAC	Suppress proliferation, induce chemosensitivity	[174,175]
Resveratrol	HAT, HDAC	Suppress proliferation, invasion, tumorigenesis in GC cells	[176,177]
Curcumin	HAT, HDAC	Suppress viability, proliferation, migration, induce autophagy, apoptosis in GC cells	[178,179]
Quercetin	HAT, HDAC	Induce apoptosis, cell cycle arrest in GC cells	[180,181]
Garcinol	HAT, HDAC, SIRTUIN	Suppress oxidation, inflammation, tumorigenesis in GC cells	[182,183]
Sodium butyrate	HAT, HDAC	Induce apoptosis in GC cells	[184]
Tenovin 6	SIRTUIN	Induce apoptosis, autophagy in GC cells	[185]
DZNEP	HMT	Suppress proliferation, apoptosis, invasion, induce apoptosis in GC cells	[186,187]
GSK126	HMT	Suppress proliferation, cell cycle angiogenesis EMT, tumorigenesis in GC cells	[188,189]
Compound 26	Lysine demethylase	Suppress growth, migration, invasion in GC cells	[190]