Effects of Helicobacter pylori infection in gastrointestinal tract malignant diseases: From the oral cavity to rectum

Table 7 Association with Helicobacter pylori infection and colorectal adenoma/ cancer

	Prevalence of H. pylori	Diagnostic tool of H. pylori	Study design	P value
Hu et al[113]	OR: 1.44; 95%CI: 1.2-1.73	Rapid urease test	Retrospective	P < 0.001
Sonnenberg et al[122]	OR: 1.52; 95%CI: 1.46-1.57	Histology	Retrospective	NA
Liou et al[124]	Case 14.2% vs controls 11.8%	13C-UBT	Case-control study	P = 0.513
Choi et al[126]	OR: 1.49; 95%CI: 1.37-1.62	Serology, histology, rapid urease test and 13C-UBT	Meta-analysis	P < 0.001
Zuo et al[127]1	OR: 1.70; 95%CI: 1.64-1.76	Serology, histology and rapid urease test	Meta-analysis	NA
Colorectal adenoma incidence decreased after H. pylori eradication
Hu et al[133]2	HR: 3.04; 95%CI: 1.754-5.280	Rapid urease test	Retrospective cohort	P < 0.001

¹For colorectal cancer.

²Second rapid urease test (+) vs (-). ¹³C-UBT: ¹³C-urea breath test; OR: Odds ratio; CI: Confidence interval; H. pylori: Helicobacter pylori; HR: Hazard ratio; NA: Not available.