Systematic Reviews
Copyright ©The Author(s) 2022.
World J Gastrointest Oncol. Jan 15, 2022; 14(1): 334-347
Published online Jan 15, 2022. doi: 10.4251/wjgo.v14.i1.334
Table 2 Potential therapeutic drugs
Exosomal content
Sample
Expression
Isolation of exosomes
Content detection
Function
Ref.
HCC
miRNAs
miR-122Serum (n = 75)DownSBIqRT-PCRReflect the liver damage and residual liver function levels[47]
Plasma (n = 150)DownSBIqRT-PCRSignificantly lower in patients with HCC compared with cirrhotic patients and the control group[22]
miRNA-1298Serum (n = 120)DownexoRNeasy Serum/Plasma MidiKit (Qiagen) qRT-PCRDown-regulated in patients of hepatocellular carcinoma compared with patients of hepatitis C virus and normal good health control[39]
miR-320aSerum (n = 209)DownSBIqRT-PCRAssociated with lymph node metastasis, vein invasion, TNM stage, and survival of HCC patients[48]
miR-320dSerum (n = 150)DownTotal Exosome Isolation Kit (Invitrogen)qRT-PCRAssociated with clinicopathological parameters and prognosis of HCC patients[49]
miR-638Serum (n = 147)DownTotal Exosome Isolation Kit (Invitrogen)qRT-PCRInfluence liver carcinogenesis [50]
miR-718Serum (n = 59)Down Ultracentrifugation qRT-PCRSignificantly different expression of HCC cases with recurrence after LT compared with those without recurrence[51]
miR-744Serum (n = 20)DownUltracentrifugationqRT–PCRFacilitates the propagation and drug resistance of HCC cells[52]
miR-9-3pSerum (n = ?)DownUltracentrifugationqRT-PCRA potential therapeutic target for HCC[53]
lncRNAs
lnc-EPC1-4Serum (n = 180)DownUltracentrifugationqRT-PCRFunction as a tumor suppressor gene[35]
SENP3-EIF4A1Serum (n = 6) Down SBIqRT-PCRBlock HCC progression[54]
circRNAs
circ-0051443Plasma (n = 120)Down SBIqRT-PCRSuppress HCC progression[55]
HB
miRNAs
miR-34sSerum (n = 152)DownSBIqRT-PCRSignificantly lower in patients with HB compared with the control group[56]