Characterization of E-cadherin expression in normal mucosa, dysplasia and adenocarcinoma of gastric cardia and its influence on prognosis

Table 3 Association of E-cadherin expression with clinicopathological features in patients with gastric cardia adenocarcinoma

Variables	Total	E-cadherin protein expression		χ2	P value
	n	Positive, n (%)	Negative, n (%)
Gender				4.645	0.031
Female	954	824 (86.4)	130 (13.6)
Male	3607	3012 (83.5)	595 (16.5)
Age at diagnosis (yr)				0.709	> 0.05
< 60	1717	1434 (83.5)	283 (16.5)
≥ 60	2844	2402 (84.5)	442 (15.5)
Family history				1.018	> 0.05
Negative	3366	2820 (83.8)	546 (16.2)
Positive	1195	1016 (85.0)	179 (15.0)
Cigarette smoking				1.408	> 0.05
No	2166	1841 (85.0)	325 (15.0)
Yes	2395	2005 (83.7)	390 (16.3)
Alcohol consumption				0.011	> 0.05
No	3206	2706 (84.4)	500 (15.6)
Yes	1355	1142 (84.3)	213 (15.7)
Differentiation				14.259	0.001
Well	133	123 (92.5)	10 (7.5)
Moderate	2039	1742 (85.4)	297 (14.6)
Poor	2389	1971 (82.5)	418 (17.5)
T status				22.490	< 0.001
pT1	71	63 (88.7)	8 (11.3)
pT2	308	278 (90.3)	30 (9.7)
pT3	3044	2580 (84.8)	464 (15.2)
pT4	1138	915 (80.4)	223 (19.6)
Lymph node metastasis				0.481	> 0.05
Negative	1637	1385 (84.6)	252 (15.4)
Positive	2924	2451 (83.8)	473 (16.2)
Staging				10.941	0.001
Early stage	191	177 (92.7)	14 (7.3)
Advanced stage	4370	3659 (83.7)	711 (16.3)