Prognostic value of modified Lauren classification in gastric cancer

Table 3 Comparison of predictive performances between different pathological classifications and prognostic models

Pathological classification/prognostic model	AUC (95%CI)		AIC
	3-yr overall survival	5-yr overall survival
Differentiation grade	0.626 (0.608–0.644)	0.621 (0.602–0.639)	25971
Lauren classification	0.666 (0.647–0.683)	0.681 (0.663–0.699)	25923
Modified Lauren classification	0.679 (0.661–0.696)	0.702 (0.685–0.719)	25877
DeLong tests for AUCs
Differentiation grade vs Lauren	P < 0.001	P < 0.001	–
Lauren vs modified Lauren	P < 0.001	P < 0.001	–
Modified Lauren vs differentiation grade	P < 0.001	P < 0.001	–
Novel prognostic model	0.803 (0.786–0.819)	0.804 (0.787–0.820)	20010
Age, tumor size, retrieved lymph nodes, pT stage, pN stage, modified Lauren classification
Control model	0.776 (0.759–0.793)	0.776 (0.759–0.793)	20144
AJCC 8th pTNM stage (pT stage, pN stage)

AIC: Akaike's Information Criterion; AJCC: American Joint Committee on Cancer; AUC: Area under curve; pN stage: Pathological N stage; pT stage: Pathological T stage. A higher area under the curve indicated better model discrimination and a lower Akaike's Information Criterion indicates superior model-fitting; Differentiation grade, well vs moderate vs poor vs undifferentiation; Lauren classification, intestinal type vs diffuse type vs mixed type; Modified Lauren classification, distal non-diffuse vs proximal non-diffuse vs diffuse type.