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©The Author(s) 2021.
World J Gastrointest Oncol. Jul 15, 2021; 13(7): 693-705
Published online Jul 15, 2021. doi: 10.4251/wjgo.v13.i7.693
Published online Jul 15, 2021. doi: 10.4251/wjgo.v13.i7.693
Figure 7 Mechanism by which cryptotanshinone regulates Src homology 2 domain–containing phosphatase 2 and cytotoxin-associated gene A-associated pathogenesis in gastric cancer.
Cryptotanshinone (CTS) suppresses the expression of Src homology 2 domain–containing phosphatase 2 (SHP2), which prevents cytotoxin-associated gene A (CagA) from phosphorylating SHP2. Therefore, CTS inhibits CagA-induced proliferation and the epithelial-mesenchymal transition (EMT) in gastric cancer (GC) and mucosal erosion in the stomach of mice.
- Citation: Chen ZM, Hu J, Xu YM, He W, Meng L, Huang T, Ying SC, Jiang Z, Xu AM. Cryptotanshinone inhibits cytotoxin-associated gene A-associated development of gastric cancer and mucosal erosions. World J Gastrointest Oncol 2021; 13(7): 693-705
- URL: https://www.wjgnet.com/1948-5204/full/v13/i7/693.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v13.i7.693