Targeting of elevated cell surface phosphatidylserine with saposin C-dioleoylphosphatidylserine nanodrug as individual or combination therapy for pancreatic cancer

Figure 4 Variable surface phosphatidylserine on pancreatic ductal adenocarcinoma tumor cells are sensitive to phosphatidylserine-selective treatments. Chemotherapy and radiation target primarily low surface phosphatidylserine (PS) cells and may increase PS. Saposin C-dioleoylphosphatidylserine (SapC-DOPS) hones in on high surface PS cells in the acidic tumor microenvironment. Thus, a combination of chemotherapy and/or radiation therapy and SapC-DOPS has the potential to eliminate the preponderance of tumor cells. PDAC: Pancreatic ductal adenocarcinoma.