Application of the woodchuck animal model for the treatment of hepatitis B virus-induced liver cancer

Table 1 Imaging techniques and contrast agents applied for the detection of woodchuck hepatocellular carcinoma

Imaging technique	Contrast agent	Brand name	Ref.
Ultrasonography	Air-filled albumin microspheres		[195]
	Cyanacrylate polymer microparticles	SHU563A	[196]
	Dodecafluoropentane emulsion	EchoGen	[197,198]
	Galactose microparticles/palmitic acid	Levovist	[199-201]
	Perflexane-filled lipid microspheres	Imagent	[202]
	Perfluoropropane-filled albumin microspheres	Optison/FS069	[95,200,201,203,204]
Scintigraphy	99mTc-sulfur colloid		[205]
Positron-emission tomography	[1-11C]acetate		[206-208]
	[1-14C]acetate		[207]
	[N-methyl-11C]choline		[206,209,210]
	[18F]clofarabine		[211]
	[18F]fluoro-ethylcholine		[210]
	Anti-1-amino-3-[18F]fluoro-cyclobutyl-1-carboxylic acid		[212]
	2-deoxy-2-[18F]fluoro-D-glucose		[208,209,213]
	6-deoxy-6[18F]fluoro-D-glucose		[206,209,210]
	L-[S-methyl-11C]methionine		[212]
	3-deoxy-3-[18F]fluoro-thymidine		[214]
Magnetic resonance imaging	Gadolinium	Gadavist or Omniscan	[157,179,185]
	Gadopentetate dimeglumine	Magnevist	[158,189]
	Iron oxide		[215,216]
Computed tomography	Biodegradable radiopaque fiducial markers based on polymers and iodine	Ioversol, Isovue-370, Optiray300, or Optiray350	[152,153,159,186,206]
	Diatrizoic acid	Angiografin	[190]
	Meglumine iotroxate	Biliscopin	[151]
	Iohexol	Omnipaque or Omnipaque350	[157,188]