Latest therapeutic target for gastric cancer: Anthrax toxin receptor 1

Table 1 Biological function of anthrax toxin receptor 1

Biological function of ANTXR1	Summary of findings	Ref.
Non-tumor related biological function	Regulates extracellular matrix homeostasis	Sergeeva et al[6] and Hu et al[7]
	Regulates angiogenesis	Sergeeva et al[6] and Besschetnova et al[8]
	Regulates cell migration, and skin elasticity.	Sergeeva et al[6]
	Regulates the proliferation and apoptosis of chondrocytes	Jiang et al[9]
Tumor related biological function	Regulates tumor growth and Metastasis	Høye et al[10] and Evans et al[12]
	Overexpress in gastric adenocarcinoma	Sotoudeh et al[11]
	Active the PI3K/AKT/mTOR signaling pathway	Cai et al[19]
	Mediates uPA-stimulated EGFR phosphorylation	Zhang et al[13]
	Promotes tumor angiogenesis	Nanda et al[16] and Chaudhary et al[17]

uPA: Urokinase plasminogen activator.