Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure

Table 5 Acute toxicity during systemic chemotherapy in both treatment groups

Toxicity during systemic ChT	Adjuvant ChT (standard therapy), 50 patients						During induction and consolidation ChT (TNT), 89 patients
	Grade 1-2		Grade 3		Grade 4		Grade 1-2		Grade 3		Grade 4
Thrombocytopenia	7	14%	0		0		11	12%	0		0
Anaemia	15	30%	0		0		12	13%	0		0
Neutropenia	3	6%	0		0		8	9%	0		0
Diarrhoea	6	12%	1	2%	0		10	11%	0		0
Nausea	2	4%	1	2%	0		29	33%	0		0
Vomiting	2	4%	1	2%	0		8	9%	0		0
Hand foot syndrome	15	30%	5	10%	0		10	11%	1	1%	0
Paraesthesia	1	2%	0		0		54	61%	0		0
Acute renal failure	1	2%	0		0		0		0		0
Rectal fistula	0		1	2%	0		0		0		0
Stoma site infection	1	2%	1	2%	0		0		0		0
Hepatotoxicity	0		0		0		3	3	0		0
Infection	5	10%	0		0		2	2%	1	1%	0
Chest pain	0		0		0		1	1%	0		0
Thromboembolism	5	10%	0		0		1	1%	1	1%	0
Ileus	1	2%	0		0		1	1%	0		0
Enterocolitis	0		0		0		1	1%	0		0
Without toxicity	12 (24%)						16 (18%)

ChT: Chemotherapy; TNT: Total neoadjuvant treatment.