BRAFV600E mutant colorectal cancer cells mediate local immunosuppressive microenvironment through exosomal long noncoding RNAs

Figure 2 Screening and functional analysis of differentially expressed long noncoding RNAs and mRNAs in exosomes of BRAF^V600E mutant colorectal cancer cells and those with BRAF gene silencing. A: Transcriptomics analysis of differentially expressed long noncoding RNAs (lncRNAs) and mRNAs in the exosomes of HT29 and 1627 cells. Volcano maps are shown (the x axis represents the multiple of difference, and the y axis P values); B: Hierarchical cluster analysis of differentially expressed lncRNAs and mRNAs (red represents upregulated expression, and blue represents downregulated expression); C: GO enrichment analysis of differentially expressed lncRNA target genes and mRNAs; D: KEGG pathway analysis of differentially expressed lncRNA target genes and mRNAs. LncRNA: Long noncoding RNA.