Cell-free DNA liquid biopsy for early detection of gastrointestinal cancers: A systematic review

Table 5 Sensibility and sensitivity of included studies

	Ref.	Group of validation cohorts	Sensitivity	Specificity	Positive predictive value	Negative predictive value	AUC
PDCA	Li et al[13]	Cancer vs healthy	93.2	95.2	NA	NA	0.943
	Chen et al[14]	Cancer vs healthy	NA	NA	NA	NA	0.921
HCC	Guler et al[18]	HBV-related HCC vs cancer-free HBV group 1	18	97.4	NA	NA	0.92
		HBV-related HCC vs cancer-free HBV group 2	29	95.6	NA	NA	0.81
	Junca et al[12]	HCC vs cancer-free HBV	100	94	17	100	NA
	Tao et al[15]	HCC vs healthy	82.7	76.4	NA	NA	0.884
		HCC vs high risk (HBV and cirrhosis)	82.7	67.4	NA	NA	0.846
Various cancer types	Cristiano et al[19]	Pre-diagnosis vs healthy	84.9	96.1	NA	NA	NA
		Post-diagnosis vs healthy	87.5	96.1
	Li et al[17]	All cancer vs healthy	80	95	NA	NA	0.94
			73	98
		Gastric cancer vs healthy	81	95
			81	98
		Colorectal cancer vs healthy	81	95
			70	98
		Bile duct cancer vs healthy	88	95
			81	98
		Pancreatic cancer vs healthy	71	95
			65	98
	Qu et al[16]	All cancer vs healthy	74.2	73.5	87.1	52.1	NA
		Colorectal cancer vs healthy	78.4	69.9	48.3	90
Colorectal	Cai et al[11]	Cancer/adenoma vs healthy	16.9	100	100	59.2	NA
	Wan et al[9]	Cancer vs healthy	74	90	NA	NA	0.887
	Jensen et al[20]	Cancer vs healthy	85	85	NA	Na	0.92
	Nunes et al[21]	Cancer vs healthy	85	99	NA	NA	NA
	Perrone et al[22]	Cancer vs healthy	NA	NA	NA	NA	0.709
		Adenomas vs healthy	NA	NA	NA	NA	0.535

HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; PDAC: Pancreatic ductal adenocarcinoma.