Genetic variation of TGF-ΒR2 as a protective genotype for the development of colorectal cancer in men

Table 4 TGFBR2G^[-875]A rs3087465 polymorphism distribution in advanced CRC cases compared to healthy controls

TGFBR2 -875G/A (rs3087465)	Advanced CRC, n (%)	Healthy controls, n (%)	OR (95%CI)	P value
Total n	96 (52.2)	307 (100)
GG	64 (66.7)	193 (62.9)	Reference
GA	29 (30.2)	102 (33.2)	0.857 (0.520-1.414)	0.546
AA	3 (3.1)	12(3.9)	0.754 (0.206-2.756)	0.668
				c 0.940
GA + AA	32 (33.3)	114	0.846 (0.522-1.373)	0.499
GA vs GG + AA	29 vs 67	102 vs 205	0.870 (0.530-1.429)	0.582
G allele	157 (81.8)	488 (79.5)	Reference
A allele	35 (18.2)	126 (20.5)	0.863 (0.570÷1.308)	0.488
Female	35 (36.5)	240
GG	22 (62.9)	159 (66.3)	Reference
GA	12 (34.3)	72 (30)	1.205 (0.565-2.567)	0.629
AA	1 (2.9)	9 (3.7)	0.803 (0.097-6.647)	0.839
				c 1.000
GA + AA	13 (37.1)	81 (33.8)	1.160 (0.556-2.421)	0.693
G allele	56 (80)	390 (81.3)	Reference
A allele	14 (20)	90 (18.7)	1.083 (0.578-2.032)	0.803
Male	61 (63.5)	67
GG	42 (68.9)	34 (50.7)	Reference
GA	17 (27.9)	30 (44.8)	0.459 (0.217-0.969)	0.039
AA	2 (3.3)	3 (4.5)	0.540 (0.085-3.417)	0.507
				c 0.841
GA + AA	19 (31.1)	33 (49.3)	0.466 (0.226-0.961)	0.037
GG vs GA + AA	42 vs 19	34 vs 33	2.146 (1.041-4.422)	0.037
GA vs GG + AA	17 vs 44	30 vs 37	0.477 (0.228-0.997)	0.047
G allele	101 (82.8)	98 (73.1)	Reference
A allele	21 (17.2)	36 (26.9)	0.566 (0.309-1.037)	0.064

c: Corrected; CRC: Colorectal cancer.