Liver tumors in children with chronic liver diseases

Table 2 Liver tumors identified in chronic liver diseases

Liver disease and main pathogenesis	Tumor type
Genetic or metabolic syndromes
Hereditary tyrosinemia type 1[80-83]	HCC
GSD type 1, 3, 4	HA, HCC, HB
Alagille syndrome	HCC, regenerative nodule
Other familial cholestatic syndromes	HCC
NAFLD	HCC
α-1 antitrypsin deficiency	HCC
Infections
HBV	HCC
HCV	HCC
Vascular
Abernethy	FNH, HCC, HA
Noncirrhotic portal hypertension	NRH
Congenital portosystemic shunt	HCC, HB
Cirrhosis and cholestatic conditions
Biliary atresia	HCC, FNH, pseudotumor
Autoimmune hepatitis	HCC
Wilson disease	HCC
Congenital hepatic fibrosis	HCC
Cryptogenic cirrhosis	HCC

FNH: Focal nodular hyperplasia; GSD: Glycogen storage disease; HA: Hepatic adenoma; HB: Hepatoblastoma; HBV: Hepatitis B virus; HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus; NAFLD: Non-alcoholic fatty liver disease; NRH: Nodular regenerative hyperplasia.