Novel perspective in pancreatic cancer therapy: Targeting ferroptosis pathway

Table 1 Features of ferroptosis and other forms of regulated cell death

	Ferroptosis	Necrosis	Apoptosis	Autophagy
Morphological features	Condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture	Organelle swelling, plasma membrane damage, cell disruption	Cell membrane foaming, cell shrinkage and the formation of apoptotic bodies	Cytoplasm vacuolization, formation of autophagosomes and removal of substances through lysosomes
Biochemical features	Iron accumulation; lipid peroxidation; glutaminolysis	Activation of RIPK1, RIPK3, and MLKL; activation of inflammasome and release of pro-inflammatory cytokines	DNA fragmentation; Caspases cascade activation; Ca2+/mg2+ -dependent endogenous nuclease and calpain activation	MAP1LC3B-I to MAP1LC3B-II conversion; increased autophagic flux and lysosomal