Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Sep 15, 2020; 12(9): 1056-1064
Published online Sep 15, 2020. doi: 10.4251/wjgo.v12.i9.1056

Table 3 Correlation between methylation status and malignancy with partial correlation controlling for patients’ gender and age

Rank correlation	Kendall		Partial
Possible confounders	Kendall		Gender	Age
Malignant cysts	Correlation	P value	Correlation	Correlation

NESP55 hypermethylation	0.539	0.003	0.545	0.519
GNASAS hypermethylation	0.431	0.015	0.459	0.584
GNASXL hypermethylation	0.434	0.011	0.461	0.356
GNAS1A hypermethylation	0.160	0.361	0.191	0.147
GNAS locus methylation changes	0.837	<0.001	0.870	0.825

GNAS: Guanine nucleotide-binding protein, alpha stimulating.

Citation: Faias S, Duarte M, Pereira L, Chaves P, Cravo M, Dias Pereira A, Albuquerque C. Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts. World J Gastrointest Oncol 2020; 12(9): 1056-1064
URL: https://www.wjgnet.com/1948-5204/full/v12/i9/1056.htm
DOI: https://dx.doi.org/10.4251/wjgo.v12.i9.1056

Faias S, Duarte M, Pereira L, Chaves P, Cravo M, Dias Pereira A, Albuquerque C. Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts. World J Gastrointest Oncol 2020; 12(9): 1056-1064 [PMID: 33005298 DOI: 10.4251/wjgo.v12.i9.1056]

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