Comparison of hyperthermic intraperitoneal chemotherapy regimens for treatment of peritoneal-metastasized colorectal cancer

Table 2 Impact of hyperthermic intraperitoneal chemotherapy regimen on perioperative outcome, n (%)

Parameter	Total, n = 102	Mitomycin, n = 34	Oxaliplatin/5-FU, n = 68	P value1
Median operative time in min	379 (95-774)	410 (95-774)	363 (96-722)	0.260
Median blood substitution in mL	105 (0-1800)	185 (0 -1800)	66 (0-1200)	0.068
Hospitalization in d	12 (2-46)	11,4 (4-35)	12,4 (2-46)	0.315
ICU stay in d	6.3 (2-50)	4.4 (2-9)	7.2 (2-50)	0.035a
In-hospital mortality
Rate of complications	57 (56)	12 (35)	45 (66)	0.003b
Cardio-pulmonary morbidity
Pneumonia	5 (5)	2 (6)	3 (4)	0.542
Re-intubation	2 (2)	0	2 (3)	0.442
Pulmonary embolism/thrombosis	2 (2)	0	2 (3)	0.442
Hematoma	2 (2)	1 (3)	1 (2)	0.558
Postoperative haemorrhage	4 (4)	1 (3)	3 (4)	0.593
Surgical morbidity
Intestinal atony	23 (23)	3 (9)	20 (30)	0.015a
Wound infection	15 (15)	5 (15)	10 (15)	0.608
Abdominal abscess	13 (13)	5 (15)	8 (12)	0.448
Abdominal infection	15 (15)	1 (3)	14 (21)	0.013a
Burst abdomen	8 (8)	1 (3)	7 (10)	0.184
Peritonitis	6 (6)	0	6 (9)	0.081
Sepsis	6 (6)	0	6 (9)	0.081
Renal complications
Urinary retention	4 (4)	0	4 (6)	0.192
Renal failure	7 (7)	2 (6)	5 (7)	0.344
Urinary tract infections	8 (8)	0	8 (12)	0.034a
Severity of complicationsb				0.029a
Grade 0/I	45 (44)	22 (65)	23 (34)
Grade II	23 (23)	3 (9)	20 (30)
Grade IIIa	16 (16)	5 (15)	11 (16)
Grade IIIb	10 (10)	3 (9)	7 (10)
Grade IV	8 (8)	1 (3)	7 (10)
Grade V (in-hospital mortality)	0	0	0
Mortality				0.139
30 d	5 (5)	4 (12)	1 (1)
90 d	11 (10)	5 (15)	6 (9)

¹Mann-Whitney U test/Fishers exact test.

^aP < 0.05.

^bP < 0.01. 5-FU: 5-Fluorouracil; ICU: Intensive care unit.