Maspin subcellular expression in wild-type and mutant TP53 gastric cancers

Table 4 Correlation between clinicopathological factors and Maspin expression

Clinicopathological parameter		Number(n = 266)	aTumor core (n = 266)				aP value	bInvasion front (n = 266)			bP value
			Negative (n = 39)	Cytoplasm(n = 125)	Mixed (n = 85)	Nuclear (n = 17)		Negative (n = 21)	Mixed(n = 201)	Nuclear (n = 44)
Age (yr)	≤ 60	96	8	37	39	12	< 0.01	5	85	6	> 0.05
	> 60	170	31	88	46	5		16	116	38
Localization	Proximal/middle	155	21	80	44	10	> 0.05	15	117	23	0.05
	Distal and antrum	95	17	34	41	3		6	84	5
	Diffuse localization	16	1	11	0	4		0	0	16
Microscopy	G1+2	75	10	41	22	2	0.01	5	65	5	> 0.05
	G3	76	16	42	14	4		8	54	14
	Papillary	10	0	5	5	0		0	10	0
	Poorly cohesive	53	10	19	20	4		8	35	10
	Signet ring cell	25	2	1	18	4		0	16	9
	Micro-glandular	27	1	17	6	3		0	21	6
Budding degree (Dyscohesivity)	Nodular	34	5	20	9	0	< 0.05	0	34	0	> 0.05
	≤ 5 buds/HPF	17	1	10	5	1		0	14	3
	5-9 buds/HPF	50	7	25	15	3		4	41	5
	≥ 10 buds/HPF	60	18	27	13	2		7	40	13
	Diffuse	105	8	43	43	11		10	72	23
pT stage	pT1,2	37	3	21	10	3	> 0.05	0	21	16	> 0.05
	pT3,4	229	36	104	75	14		21	180	28
pN stage	pN0	53	9	19	20	5	> 0.05	3	43	7	> 0.05
	pN1-3	213	30	106	65	12		18	158	37
Dukes-MAC-like stage	1+3 - T1,2N0	17	3	11	3	0	> 0.05	0	17	0	> 0.05
	2+4 - T1,2N1-3	20	0	12	5	3		0	17	3
	5+7 – T3,4N0	36	6	12	15	3		3	24	9
	6+8 – T3,4N1-3	193	30	90	62	11		18	143	32

G1: Well differentiated, G2: Moderately differentiated, G3: Poorly differentiated; pT: Depth of tumor infiltration; pN: Lymph node status.