Association between interleukin-21 gene rs907715 polymorphism and gastric precancerous lesions in a Chinese population

Table 4 Comparison of the genotype distribution of the IL-21 gene polymorphisms in gastric precancerous lesions

SNPs set	Geno-type	Control (n = 290, %)	NAG (n = 116, %)	AG (n = 106, %)	IM (n = 366, %)	OR1	P1 value	OR2	P2 value	OR3	P3 value	OR4	P4 value	OR5	P5 value
rs907715	TT	70 (24.1)	25 (21.6)	19 (17.9)	63 (17.2)	-		-		-		-		-
	CT	143 (49.3)	53 (45.7)	50 (47.2)	170 (46.5)	1.04 (0.60-1.81)	0.896	1.29 (0.71-2.35)	0.408	1.32 (0.88-1.98)	0.179	1.25 (0.87-1.80)	0.230	1.13 (0.62-1.74)	0.439
	CC	77 (26.6)	38 (32.7)	37 (34.9)	133 (36.3)	1.38 (0.76-2.52)	0.290	1.77 (0.93-3.36)	0.079	1.92 (1.24-2.98)	0.004	1.77 (1.19-2.63)	0.005	1.59 (1.06-2.38)	0.013
	C	220 (75.9)	91 (78.4)	87 (82.1)	303 (82.8)	1.16 (0.69-1.94)	0.578	1.46 (0.83-2.56)	0.190	1.53 (1.04-2.24)	0.028	1.43 (1.02-2.01)	0.039	1.28 (1.01-2.22)	0.044
rs12508721	TT	39 (13.4)	14 (12.1)	18 (17.0)	54 (14.8)	-		-		-		-		-
	CT	151 (52.1)	57 (49.1)	55 (51.9)	178 (48.6)	1.05 (0.53-2.08)	0.885	0.79 (0.42-1.50)	0.467	0.85 (0.54-1.36)	0.498	0.87 (0.57-1.33)	0.525	0.82 (0.55-1.28)	0.618
	CC	100 (34.5)	45 (38.8)	33 (31.1)	134 (36.6)	1.25 (0.62-2.54)	0.529	0.72 (0.36-1.42)	0.335	0.97 (0.60-1.57)	0.895	0.96 (0.62-1.50)	0.863	0.88 (0.59-1.33)	0.879
	C	251 (86.6)	102 (87.9)	88 (83.0)	312 (85.2)	1.13 (0.59-2.17)	0.709	0.76 (0.41-1.40)	0.375	0.90 (0.58-1.40)	0.634	0.91 (0.60-1.36)	0.639	0.83 (0.49-1.19)	0.801
rs2221903	TT	231 (79.7)	90 (77.6)	83 (78.3)	271 (74.0)	-		-		-		-		-
	CT	52 (17.9)	24 (20.7)	21 (19.8)	80 (21.9)	1.19 (0.69-2.04)	0.539	1.12 (0.64-1.98)	0.685	1.31 (0.89-1.94)	0.173	1.25 (0.87-1.79)	0.223	1.08 (0.53-1.55)	0.459
	CC	7 (2.4)	2 (1.7)	2 (1.9)	15 (4.1)	0.73 (0.15-3.60)	0.701	0.80 (0.16-3.91)	0.777	1.83 (0.73-4.56)	0.190	1.41 (0.59-3.41)	0.441	1.19 (0.41-2.87)	0.503
	C	59 (20.3)	26 (22.4)	23 (21.7)	95 (26.0)	1.13 (0.67-1.91)	0.643	1.09 (0.63-1.87)	0.769	1.37 (0.95-1.99)	0.092	1.27 (0.90-1.79)	0.171	1.08 (0.81-1.48)	0.311

OR₁: NAG cases compared with controls; OR₂: AG cases compared with controls; OR₃: IM cases compared with controls; OR₄: Total gastric precancerous lesions cases compared with controls; OR₅: Adjusted by age, gender, BMI, drinking status, smoking status, daily salt intake and region. SNPs: Single nucleotide polymorphisms; NAG: Non-atrophic gastritis; AG: Atrophic gastritis; IM: Intestinal metaplasia.