Prognostic scoring system for synchronous brain metastasis at diagnosis of colorectal cancer: A population-based study

Table 2 Univariate analysis of prognostic factors in patients with brain metastasis from colorectal cancer

Variable	Median survival (mo)	HR	95%CI	P value
Age (yr)
< 60	8	1	-	-
60-74	4	1.398	1.082-1.807	0.010
≥ 75	3	2.434	1.787-3.315	< 0.001
Race
White	5	1	-	-
Black	6	0.990	0.703-1.395	0.955
Other	4	1.309	0.889-1.926	0.172
Gender
Male	4	1	-	-
Female	6	0.932	0.743-1.169	0.543
Primary tumor site
Colon	5	1	-	-
Rectosigmoid/Rectum	6	0.849	0.656-1.098	0.211
Unknown	3	1.451	1.025-2.053	0.036
Tumor grade
Well/moderately differentiated	8	1	-	-
Poorly/undifferentiated	5	1.185	0.895-1.569	0.236
Unknown	4	1.527	1.170-1.994	0.002
Histology types
Adenocarcinoma	5	1	-	-
Mucinous carcinoma	8	0.761	0.416-1.394	0.377
Signet ring-cell carcinoma	4	0.923	0.451-1.888	0.826
Other	4	1.314	0.814-2.122	0.264
Unknown	3	2.416	1.133-5.149	0.022
CEA level
Negative	8	1	-	-
Positive	5	1.964	1.331-2.896	0.001
Unknown	4	2.149	1.431-3.225	< 0.001
T stage
T1/T2	4	1	-	-
T3/T4	6	0.942	0.669-1.326	0.731
Unknown	4	1.125	0.798-1.585	0.502
N stage
N0	5	1	-	-
N1/N2	6	0.952	0.733-1.238	0.715
Unknown	4	1.239	0.907-1.691	0.178
Extracranial metastasis to liver, lung or bone
No	6	1	-	-
Yes	4	1.400	1.071-1.831	0.014
Unknown	7	1.544	0.566-4.269	0.392

CEA: Carcinoembryonic antigen; HR: Hazard ratio.