Outcomes of neoadjuvant chemoradiotherapy followed by radical resection for T4 colorectal cancer

Table 3 Univariate and multivariate analyses for clinical parameters used to predict pCR

Variable	Univariate	Multivariate
	P value	OR (95%CI)	P value
Age (< 60 yr vs ≥ 60 yr)	0.471	0.556 (0.096-2.609)	0.464
Sex (female vs male)	0.416	1.722 (0.327-9.531)	0.515
Location (colon vs rectum)	0.107	2.615 (0.498-14.826)	0.251
cT stage (T4a vs T4b)	0.247	1.221 (0.218-7.667)	0.821
cN stage (N0 vs N+)	0.152	0.415 (0.104-1.337)	0.145
Tumor grade (WD/MD vs PD)	0.509	3.071 (0.341-70.370)	0.337
CEA (≤ 5 vs > 5)	0.894	0.611 (0.106-3.136)	0.556
Neoadjuvant chemotherapy (FOLFOX vs capecitabine)	0.037a	4.755 (2.118-88.203)	0.046a
Radiation dose (< 50 Gy vs ≥ 50 Gy)	0.265	0.507 (0.058-3.187)	0.478
Radiation-surgery interval (≤ 9 wk vs > 9 wk)	0.074	0.836 (0.013-3.061)	0.107

^aP < 0.05.

CEA: Carcinoembryonic antigen; MD: Moderately differentiated; pCR: Pathological complete response; PD: Poorly differentiated; WD: Well differentiated.