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Copyright ©The Author(s) 2019.
World J Gastrointest Oncol. Aug 15, 2019; 11(8): 579-588
Published online Aug 15, 2019. doi: 10.4251/wjgo.v11.i8.579
Table 1 Clinical patient characteristics of the selected studies
Ref.Study, PatientSource/ Energy (MeV)Liver functionVascular invasionTumor size
Bush et al[40]Phase II, 76ProtonCPC score4 patients5.5 cm (mean)
5-6 22
7-9 36
10-15 18
Hong et al[41]Phase II, 44Proton (230-250)CPC15 patients5.0 cm (median,1.9-12.0)
A 32
B 9
C 3
Chiba et al[42]Retro, 162Proton (250)CPC10 patients3.8 cm (median, 1.5–14.5)
A 82
B 62
C 10
Nakayama et al[37]Retro, 47Proton (155 to 250)CPC7 patientsN/A
A 35
B 9
C 3
Kawashima et al[43]Phase II, 30Proton (235)CPC12 patients45 cm (median,25-82)
A 20
B 10
Kim et al[44]Phase I, 27Proton (250)CPCN/A2.3-3.2 cm (median, 1.3-7)
A 24
B 3
Kato et al[45]Phase I/II, 24Carbon‐ion (290-400)CPC3 patients5.0 cm (median,2.1-8.5)
A 16
B 8
Mizumoto et al[34]Retro, 266ProtonCPCN/A< 3 cm 100
A 2033.0–4.9 cm 96
B 6050–99 cm 62
C 3> 100 cm 8
Komatsu et al[39]Retro, 343Proton, Carbon‐ionCPC92 patients< 50 277 50-100
A 26280
B 75> 100 22
C 6
Kim et al[46]Retro, 71Proton (230)CPC01.5 (median,1.0–8.5)
A 68
B 3
Shibuya et al[38]Retro, 174Carbon‐ionCPC03.0 (median,0.8‐10.3)
A 153
B 20