Histopathological characteristics of needle core biopsy and surgical specimens from patients with solitary hepatocellular carcinoma or intrahepatic cholangiocarcinoma

Table 4 Degree of concordance in the interpretation of glypican-3 staining between needle core biopsy and surgery specimen

NCB		SS
		4-tier				4-tier-based binary classification		3-tier			3-tier-based binary classification
		+++	++	+	-	+	-	++	+	-	+	-
4-tier	+++	62	1	0	0
	++	18	25	2	0
	+	2	2	15	0
	-	0	1	8	72
4-tier-based binary classification	+					127	0
	-					9	72
3-tier	++							42	5	0
	+							25	26	5
	-							0	2	103
3-tier-based binary classification	+										98	5
	-										2	103
Kappa value		0.768				0.907		0.714			0.933
P value		< 0.001				< 0.001		< 0.001			< 0.001

NCB: Needle core biopsy; SS: Surgery specime.