Glycerophospholipids pathways and chromosomal instability in gastric cancer: Global lipidomics analysis

doi:10.4251/wjgo.v11.i3.181

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Mar 15, 2019; 11(3): 181-194
Published online Mar 15, 2019. doi: 10.4251/wjgo.v11.i3.181

Table 3 Compound list (n = 17) of the significant changes between chromosomal instability and non-chromosomal instability groups using electrospray ionization positive and negative modes

Catalog	Putative ID	RT (min)	m/z	Adduct ion	VIP	FC
SM	SM(d18:1/18:0)	7.2	731.6077	[M+H]⁺	5.8	0.49
PI	PI(22:6/18:0)	5.1	909.554	[M-H]^-	1.6	1.53
PI	PI(22:3/16:0)	6.1	887.568	[M-H]^-	3.0	1.75
PE	PE(P-18:0/18:2)	9.7	726.544	[M-H]^-	2.8	1.92
	PE(P-16:0/20:5)	5.8	720.499	[M-H]^-	2.8	2.15
	PE(37:4)	5.8	754.5381	[M+H]⁺	2.9	1.77
	PE(22:6/18:1)	5.8	788.523	[M-H]^-	1.9	1.43
	PE(18:2/16:0)	6.5	716.5233	[M+H]⁺	2.7	1.52
PC	PC(38:6)	6.5	806.571	[M+H]⁺	3.2	2.06
	PC(38:4)	6.7	810.6041	[M+H]⁺	5.9	2.34
	PC(36:5)	4.8	780.5556	[M+H]⁺	5.7	2.30
	PC(33:2)	5.3	744.5562	[M+H]⁺	3.2	1.73
	PC(33:1)	6.5	746.5715	[M+H]⁺	3.2	1.59
	PC(30:0)	5.5	706.5394	[M+H]⁺	4.6	1.89
	PC(16:1/16:1)	4.6	730.5399	[M+H]⁺	4.1	1.98
	PC(16:1/16:0)	5.6	776.547	[M+FA-H]^-	4.3	1.46
DG	DG(38:4)	12.6	667.5287	[M+Na]⁺	1.6	0.66

All P value < 0.05. The protonated [M+H]⁺ and sodium adduct [M+Na]⁺ in positive mode, and deprotonated [M-H]^- and formic acid adduct [M+FA-H]^- in negative ion mode. FC: Fold changes [Chromosomal instability (CIN)/non-CIN]; PC: Phosphocholine; PE: Phosphatidylethanolamine; PI: Phosphatidylinositol; SM: Sphingomyelin; DG: Diglyceride; VIP: Variable importance in projection.

Citation: Hung CY, Yeh TS, Tsai CK, Wu RC, Lai YC, Chiang MH, Lu KY, Lin CN, Cheng ML, Lin G. Glycerophospholipids pathways and chromosomal instability in gastric cancer: Global lipidomics analysis. World J Gastrointest Oncol 2019; 11(3): 181-194
URL: https://www.wjgnet.com/1948-5204/full/v11/i3/181.htm
DOI: https://dx.doi.org/10.4251/wjgo.v11.i3.181