Difference in failure patterns of pT3-4N0-3M0 esophageal cancer treated by surgery vs surgery plus radiotherapy

Table 3 Univariate and multivariate analyses for factors affecting survival

	Univariate analysis	Multivariate analysis
	Median DFS (mo)	χ2 value	P value	HR (95%CI)	P value
Sex				0.841 (0.532-1.328)	0.457
Male	9.5	0.309	0.579
Female	8
Age (yr)				0.712 (0.530-0.957)	0.024
< 60	9	1.023	0.312
≥ 60	9.5
Pathological differentiation				1.128 (0.094-1.934)	0.071
Poor	8	6.377	0.095
Moderate	10.4
Well	9.5
Tumor location				1.423 (0.849-2.386)	0.363
Upper	6.6	3.277	0.194
Middle	9.9
Lower	8.8
Lymph node dissection				0.531 (0.222-1.186)	0.107
2-field resection	9	3.462	0.177
3-field resection	8
No. of LNs involved				1.843 (1.369-2.482)	<0.001a
≤ 2	11	13.483	< 0.001
≥ 3	8
No. of LN dissected				1.460 (0.459-4.644)	0.522
< 12	7	0.656	0.418
≥ 12	9.5
Chemotherapy				0.732 (0.552-0.971)	0.031
Yes	8	1.769	0.183
No	10
T stage				0.697 (0.441-1.124)	0.132
T3	9	0.087	0.767
T4	8
Radiotherapy	-	-	-	0.667 (0.487-0.915)	0.012a

^aP < 0.05 in both univariate and multivariate analysis. S arm: Surgery alone arm; S + R arm: Surgery + postoperative radiotherapy arm; LN: Lymph node.