Calponin 3 promotes invasion and drug resistance of colon cancer cells

Figure 4 CNN3 expression in formalin-fixed, paraffin-embedded tissues from resected colorectal cancers. A: The normal mucosa showed positive expression at the crypt bases (thick arrow) and faint to negative expression superficially (thin arrow, Magnification 40×). Note the negative tumor islets below the mucosa (arrow head); B: Well differentiated colon adenocarcinoma showing negative expression of CNN3 (thick arrow) while the stroma showed positive expression (thin arrow) serving as internal positive control (Magnification 200×); C: Well differentiated colon adenocarcinoma showing positive CNN3 expression (Magnification 200×); D: Poorly differentiated rectal adenocarcinoma showing intense positive expression (Magnification 100×). Chromogen, DAB marks the positive expression with brown color; counterstain, Mayer’s hematoxylin. CNN3: Calponin 3.