Calponin 3 promotes invasion and drug resistance of colon cancer cells

Figure 2 Functional consequences of CNN3 silencing in the SW620 metastatic colon cancer cell line. A: High silencing efficiency evidenced by barely detectable CNN3 protein band by western blot; B: Effect of CNN3 silencing on expression of epithelial to mesenchymal transition markers; note loss or reduction of mesenchymal markers after silencing; C: Invasion assay results showing reduction in the collagen invasion after silencing as detected by decreased dye elution; D: Decreased number of invaded cells on microscopic examination (Magnification 100×). CNN3: Calponin 3.