Revisiting oral fluoropyrimidine with cetuximab in metastatic colorectal cancer: Real-world data in Chinese population

Table 6 Grade 3 or above adverse events experienced by our patients

	Total (n = 95)	Oral (n = 57)	Infusional (n = 38)	P value
Any adverse events (%)	95 (100)	57 (100)	38 (100)	1.000
G3 or above adverse events (%)1	27 (28.4)	19 (33.3)	8 (21.1)	0.286
Hematologic (%)
Anaemia	64 (67.4)	36 (63.2)	28 (73.7)	0.396
G3 or above	4 (4.2)	4 (7.0)	0 (0)	0.147
Leucopenia	44 (46.3)	25 (43.9)	19 (50.0)	0.705
G3 or above	3 (3.2)	1 (1.8)	2 (5.3)	0.562
Neutropenia	49 (51.6)	26 (45.6)	23 (60.5)	0.224
G3 or above	10 (10.5)	5 (8.8)	5 (13.2)	0.514
Thrombocytopenia	53 (55.8)	37 (64.9)	16 (42.1)	0.047 a
G3 or above	5 (5.3)	5 (8.8)	0 (0)	0.081
Biochemistry (%)
Raised AST	68 (71.6)	47 (82.5)	21 (55.3)	0.008 b
G3 or above	2 (2.1)	1 (1.8)	1 (2.6)	1.000
Raised bilirubin	21 (22.1)	14 (24.6)	7 (18.4)	0.650
G3 or above	2 (2.1)	1 (1.8)	1 (2.6)	1.000
Non-hematologic (%)
Acneiform rash	58 (61.1)	36 (63.2)	22 (57.9)	0.764
G3 or above	3 (3.2)	1 (1.8)	2 (5.3)	0.562
Diarrhoea	25 (26.3)	17 (29.8)	8 (21.1)	0.476
G3 or above	2 (2.1)	2 (3.5)	0 (0)	0.515
Hand-foot syndrome	2 (2.1)	2 (3.5)	0 (0)	0.515
G3 or above	2 (2.1)	2 (3.5)	0 (0)	0.515

The incidence of thrombocytopenia^a and raised AST^b was significantly higher in the oral FU group. No significant difference was noted in the grade 3 or above adverse effects between the two treatment groups.

¹ G3 refers to grade 3.